Evaluation of the impact of low activity imaging in [11C]-(+)-PHNO and [11C]UCB-J PET-MR scans

The simulation and analysis methodologies deployed in this project are suitable for investigating scans with low injected activity for tracers with cortical and striatal uptake, when the outcome measure assessed is the BPND or the SUVR. Whilst the data suggests that imaging with low injected activity is achievable, the efficacy of the investigation is highly dependent on the algorithm used to reconstruct the images, the outcome measure and the radiopharmaceutical used to acquire the PET-MR scans. For the [¹¹C]UCB-J radiopharmaceutical, it is possible to decrease the injectable activity to 1/3 of the original administration without compromising the SUVR.