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March 13, 2026International Journal of Molecular SciencesOpen Access

A Rapid Active–Latent–Relapse Murine Model of Tuberculosis Based Blood Transcriptional Signature That Distinguishes Disease Stages

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Authors

HLHaifeng LiJWJunfei WangYWYu Wang

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Overview

Model demonstrates distinct biomarkers for tracking tuberculosis stages in murine hosts, suggesting improved diagnostics for latent infection.

Key Points

  • This research aims to create an effective murine model to study the different stages of tuberculosis and identify biomarkers that can track disease progression.
  • Developed a rapid murine model reflecting active, latent and relapse TB phases within ten weeks.
  • Infected mice intravenously with Mycobacterium tuberculosis and treated with isoniazid.
  • Conducted transcriptomic profiling of peripheral blood to identify gene signatures associated with TB stages.
  • Triggered relapse using anti-TNF-α monoclonal antibody after establishing latency.
  • Established latency in most mice by week six, indicated by low pulmonary bacterial loads.
  • Identified a distinct sixteen-gene signature linked to disease phases.
  • Provided a reproducible tool for preclinical research on tuberculosis.
  • Identified potential biomarkers for diagnosing latent tuberculosis infection.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69b3ab9102a1e69014ccc965https://doi.org/10.3390/ijms27062554
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Machine-Learning-Derived, Mechanistically Informed Transcriptomic Signature to Diagnose Active Tuberculosis and Guide Host-Directed Therapy2026 · 1 citations
  2. 2Cross species modeling reveals a role for the unfolded protein response in shaping the transcriptional reaction to<i>Mycobacterium tuberculosis</i>infection2024 · 1 citations
  3. 3Mouse models of tuberculosis uniformly featuring hypoxic necrotic lesions and poor response to chemotherapy2026
  4. 4Mouse Models Uniformly Featuring Human-like Lesions Harboring Drug-tolerant Mycobacterium tuberculosis2025
  5. 5Genome-wide transcriptional landscape of Mycobacterium tuberculosis during acute lung infection2026