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March 1, 2026Journal of Dermatological ScienceOpen Access

Single-cell RNA sequencing identifies long non-coding RNAs enriched in psoriatic epidermal subsets

Longlong Luo Jan Cedric Freisenhausen Devin Malitha Dompage H. Cheng M. Enge Andor Pivarcsi Enikö Sonkoly

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Key Points

The goal is to map lncRNA expression in healthy vs. psoriatic epidermis, focusing on cell-type specific roles.
Utilized Smart-seq2 single-cell RNA sequencing on epidermal cells from healthy and psoriatic skin.
Validated selected lncRNAs through RT-qPCR and immunofluorescence.
Investigated the role of LINC01137 in IL-17A-treated keratinocytes.
Identified 1412 epidermal lncRNAs showing distinct expression in keratinocyte and immune cell subsets.
LINC01137 expression correlates with TGF-beta pathway activity and IL-17A stimulation.
LINC00892 was prominent in psoriasis-associated Th1 and Th17 T cells.

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Implication

Single-cell RNA sequencing identifies lncRNAs linked to epidermal dysfunction in psoriasis, suggesting new insights into the disease mechanisms.

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Cite This Study

Luo et al. (2026) studied this question.

synapsesocial.com/papers/69b3abb202a1e69014cccc7f https://doi.org/10.1016/j.jdermsci.2026.03.002

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Long Non-Coding RNAs in Psoriasis: A Comprehensive Review of Expression Profiles, Mechanistic Insights, Genetic Associations, and Their Clinical Implications2025 · 5 citations
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4Non-coding RNAs in psoriasis : insights into epidermal dysregulation and inflammation2025
5Non-coding RNAs in psoriasis : insights into epidermal dysregulation and inflammation2025