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March 13, 2026Phytomedicine PlusOpen Access

Plant citronellol regulates type 1 diabetes in streptozotocin-induced diabetic rodent models

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Authors

WRWilson Joel RodriguesBNBhagya NekrakaleyaCRChandrashekar Konambi Ramaiah

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Overview

This research investigates citronellol's effects on blood glucose and kidney damage in diabetic rodents, suggesting its potential as a treatment.

Key Points

  • The aim is to assess the protective effects of citronellol on blood glucose levels and diabetic nephropathy in diabetic rodents.
  • Used streptozotocin (STZ) to induce diabetes in rat models.
  • Divided rats into four groups: normal control, diabetic control, citronellol-treated, and glibenclamide-treated.
  • Evaluated treatment effects through biochemical and histopathological analyses.
  • Conducted in-silico pharmacokinetic studies using SWISS ADME.
  • Citronellol treatment significantly lowered blood glucose levels and improved body weight in diabetic rats.
  • Enhanced regeneration of pancreatic islets and increased C-peptide release were observed.
  • Improved glycogen synthesis was noted in biochemical analyses.
  • Reduced serum urea and creatinine levels indicated amelioration of diabetic nephropathy.
  • In-silico studies revealed promising pharmacokinetic properties for citronellol.

Cite This Study

Rodrigues et al. (2026) studied this question.

synapsesocial.com/papers/69b3abb202a1e69014cccd6chttps://doi.org/10.1016/j.phyplu.2026.100978
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