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April 24, 2026Drugs and Drug CandidatesOpen Access

A Classic Citrus Monoterpene Revisited: Protective Effects of D-Limonene on Hepatic and Aortic Vascular Dysfunctions in Type 1 Diabetic Rats

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Authors

LSLeonardo da Rocha SousaNVNildomar Ribeiro VianaRNRENATO SAMPAIO MELLO NETO

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Overview

Demonstrates the benefits of D-Limonene on reducing complications in type 1 diabetes, suggesting a potential therapeutic role.

Key Points

  • This research aims to examine the antidiabetic and antioxidant properties of D-Limonene in a type 1 diabetes model.
  • Female Wistar rats were induced with diabetes using streptozotocin (STZ).
  • D-Limonene was administered at varying doses (12.5 mg/kg, 25 mg/kg, 50 mg/kg) for 28 days.
  • Biochemical parameters and oxidative stress markers were evaluated at the end of the treatment.
  • D-Limonene significantly reduced serum glucose and HbA1c levels compared to diabetic controls.
  • Aortic myeloperoxidase activity decreased, while catalase activity increased in response to D-Limonene.
  • Biochemical improvements included lowered levels of liver enzymes (AST, ALT, GGT, ALP) and oxidative stress markers.

Cite This Study

Sousa et al. (2026) studied this question.

synapsesocial.com/papers/69eb0bfa553a5433e34b5807https://doi.org/10.3390/ddc5020027
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