What question did this study set out to answer?

The aim is to develop rat models of hindlimb ischemia to study peripheral arterial disease and evaluate therapeutic strategies across different disease stages.

March 13, 2026Scientific ReportsOpen Access

Development and characterization of rat hindlimb ischemia models mimicking peripheral arterial disease severity

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YLYingxiang LiangChinese Academy of Medical Sciences & Peking Union Medical College CMConnor R. MullenWashington University in St. Louis EYEmma R. YoungWashington University in St. Louis

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Three rat hindlimb ischemia models reveal varying severity and recovery, suggesting insights for regenerative therapies.

Key Points

The aim is to develop rat models of hindlimb ischemia to study peripheral arterial disease and evaluate therapeutic strategies across different disease stages.
Established three hindlimb ischemia models: iliac, femoral, and femoral plus popliteal artery ligation and excision.
Used laser Doppler perfusion imaging to assess blood flow reduction and recovery.
Conducted histological and morphometric analyses to evaluate muscle remodeling at chronic endpoint.
Blood flow reduction was 60-65% in Iliac, 40-50% in Femoral, and <30% in Fem/Pop.
Iliac model showed earliest perfusion recovery, while Fem/Pop displayed the most sustained ischemia and muscle remodeling.
Histological analysis revealed increased muscle degeneration and fibrosis in Fem/Pop model, with varying oxidative stress markers.

Cite This Study

Liang et al. (2026) studied this question.

synapsesocial.com/papers/69b3ac3f02a1e69014ccdcf9 https://doi.org/10.1038/s41598-026-43361-7

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Development and characterization of rat hindlimb ischemia models mimicking peripheral arterial disease severity

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Key Points

Cite This Study

Development and characterization of rat hindlimb ischemia models mimicking peripheral arterial disease severity

Discussion

Member takes

Implication

Key Points

Cite This Study

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