Key result
Iliac artery ligation cuts femoral flow by ~59% versus the contralateral limb in rat models.
Why the study?
Reperfusion injury causes failure in up to 15% of lower limb bypass procedures and complications in other surgeries, but most experimental work has focused on acute ischaemia in normal tissues rather than chronic ischaemia in compromised distal limb circulation.
Population
Anaesthetised rats with chronic hind limb ischaemia
Comparison
Ligation of left common iliac artery vs contralateral limb
Design
Experimental model of chronic ischaemia in rats
Follow-up
Up to nine weeks
Authors
Loading...
Rat iliac ligation sustains chronic limb ischemia; leaves open translation to human reperfusion studies.
Ligation of the left common iliac artery in rats creates a stable model of chronic lower limb ischaemia for up to nine weeks, suitable for studying reperfusion injury.
Rochester et al. (2008) studied Chronic lower limb ischaemia. Ligation of the left common iliac artery vs. Contralateral limb was evaluated on Femoral artery blood pressure and flow. Ligation of the left common iliac artery in rats reduced femoral artery blood pressure and flow to 53% and 41% respectively compared to the contralateral limb, maintaining chronic ischaemia for up to nine weeks.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: