Key result
Adenosine in newborn rats decreases early parasympathetic influence but increases it by 30 days.
Why the study?
Does exogenous adenosine affect heart rate variability indices in newborn rats?
Does exogenous adenosine affect heart rate variability indices in newborn rats?
Exogenous adenosine produces a prolonged negative chronotropic effect and age-dependent changes in parasympathetic regulation of heart rhythm in newborn rats.
Answers are grounded in this paper and cite their sources.
May warrant caution extrapolating adult adenosine data to neonates; extends knowledge of developmental parasympathetic maturation.
The dynamics of HR variability (HRV), HR, and respiratory rate (RR) under baseline conditions and after intraperitoneal administration of adenosine at a dose of 90 mg/kg was analyzed in rats aged 3 (P3), 16 (P16), and 30 (P30) days. In newborn rats, a prolonged negative chronotropic effect of adenosine was revealed, unlike the transient effect typical of adult animals. It was found that qualitatively different changes in the mechanisms regulating heart rhythm occur between P3-P16 and P30 after exogenous activation of adenosine receptors. Activation of adenosine receptors is accompanied by a significant decrease in parasympathetic influences during the first two weeks and their significant increase by 30 days. During the first month of life, adenosine administration has no significant effects on sympathetic and neurohumoral factors of heart rhythm regulation.
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Kuznetsov et al. (2026) studied this question. Adenosine administration in newborn rats significantly decreased parasympathetic influences in the first two weeks and increased them by 30 days, indicating developmental changes in heart rate regulat.
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