Population
1 to 20 day-old neonatal rat heart tissue (atria and ventricles)
Comparison
(-)-adrenaline vs Resting performance and different age groups
Design
Preclinical
Authors
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Neonatal rat findings highlight developmental cardiac signaling gaps; leaves open human translation and clinical relevance.
Neonatal rat ventricles show a dissociation between cyclic AMP production and inotropic force response to adrenaline in the first few days of life, suggesting immature receptor-response transduction.
Au et al. (1980) studied this question.
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