Why the study?
Do the cardiovascular effects of adenosine and the adenosine A1 receptor antagonist NPC 205 vary with age in guinea pigs?
Population
Guinea pigs in two age groups: young (3-4 weeks) and older (72-75 weeks)
Comparison
Exogenously administered adenosine… vs Comparison between young and older age groups
Design
Preclinical
Authors
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Suggests caution extrapolating adenosine dosing to elderly patients; leaves open metabolic mechanisms for human validation.
Do the cardiovascular effects of adenosine and the adenosine A1 receptor antagonist NPC 205 vary with age in guinea pigs?
Age-related differences in cardiovascular sensitivity to adenosine in guinea pigs may be driven by changes in adenosine metabolism rather than receptor sensitivity.
Garavilla et al. (1993) studied this question.
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