Why the study?
Does age affect the chronotropic and inotropic responses to A1 adenosine receptor activation in rat atrial tissue?
Does age affect the chronotropic and inotropic responses to A1 adenosine receptor activation in rat atrial tissue?
Senescent rat atria show increased sensitivity to the negative chronotropic effects of adenosine A1 receptor stimulation and increased receptor density, suggesting a role for adenosine in age-related abnormal sinus node function.
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Hypothesis-generating for adenosine in age-related sinus node dysfunction in rats; leaves open translation to human atrial responses.
Montamat et al. (1996) studied this question.
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