Population
Adult and senescent New Zealand White rabbits
Comparison
N6-R-phenylisopropyladenosine, an adenosine A1… vs Comparison between adult and senescent rabbit…
Design
Preclinical
Authors
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Should not yet change adenosine use in elderly patients; leaves open whether A1 upregulation drives age-related contractile decline in humans.
Senescent rabbit myocardium exhibits increased sensitivity to the negative inotropic effects of adenosine A1 receptor activation, likely driven by an age-related increase in A1 receptor density.
Mudumbi et al. (1995) studied this question.
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