Comparative analysis reveals effects of charged groups on sensitizing activity and biodistribution in biological systems, indicating implications for therapeutic applications.
New data have been obtained that expand the understanding of the role of the chemical structure and physico-chemical properties of photosensitizer molecules in determining the processes of their interaction with various biological objects, including serum proteins, biological membranes, cells and cellular systems. Changes in the side substituents in the chlorin e6 molecule significantly affect the physico-chemical properties of new compounds, the level of their accumulation in cells, and the rate of migration between cells, but do not significantly affect the intracellular localization of sensitizers. It is assumed that the increased photosensitizing activity of chlorin e6 derivatives is due to the effect of lateral substituents on their biodistribution processes.
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Zorina et al. (2025) studied this question.
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