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This review aims to explore the mechanisms of lactylation in cancer and its therapeutic implications.

March 13, 2026MedCommOpen Access

Protein Lactylation in Cancer: Mechanisms and Therapeutic Targets

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Review highlights lactylation's role in cancer therapies, suggesting new targets and strategies for treatment.

This review aims to explore the mechanisms of lactylation in cancer and its therapeutic implications.
Examined the role of lactate in the tumor microenvironment and its link to lactylation.
Analyzed existing literature on lactylation's impact on cancer therapies and mechanisms.
Identified regulatory factors that influence lactylation and its potential as a therapeutic target.
Lactate contributes to the acidic tumor microenvironment, affecting cancer cell behavior.
Lactylation is linked to epigenetic reprogramming and tumor progression.
Targeting lactylation could improve outcomes by enhancing chemotherapy efficacy and overcoming tumor heterogeneity.

Ouyang et al. (2026) studied this question.

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