Clinical profile and prognosis of brugada syndrome SCN5A variant carriers with negative sodium channel blocker challenge

Elodie Surget; Gael Clerici; Frédéric Sacher; Raphael Martins; Philippe Maury; Isabelle Denjoy; Aurélie Thollet; Julien Barc; Jean Jacques Schott; Nico Drapier; Richard Redon; JEAN BAPTISTE GOURRAUD; V Probst

doi:10.1093/europace/euag014

February 27, 2026EP Europace

Clinical profile and prognosis of brugada syndrome SCN5A variant carriers with negative sodium channel blocker challenge

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Key Points

To assess prognosis and clinical characteristics of SCN5A variant carriers with a negative sodium channel blocker challenge.
Multicentre analysis of SCN5A variant carriers
Inclusion of patients with negative sodium channel blocker challenge
Longitudinal monitoring for arrhythmic events
Excellent arrhythmic prognosis observed in carriers
Frequent progressive conduction slowing noted within the cohort
Largest analysis of its kind conducted

Implication

Multicentre study shows excellent arrhythmic prognosis in Brugada syndrome with SCN5A variants despite conduction slowing.

Abstract

This multicentre study provides the largest analysis of SCN5A carriers with negative SCBC, showing excellent arrhythmic prognosis despite frequent progressive conduction slowing.

Discussion

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Cite This Study

Surget et al. (2026) studied this question.

synapsesocial.com/papers/69b4ad7918185d8a39800bad https://doi.org/10.1093/europace/euag014

View at Publisher

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Clinical profile and prognosis of brugada syndrome SCN5A variant carriers with negative sodium channel blocker challenge

Key Points

Implication

Abstract

Discussion

Cite This Study

Clinical profile and prognosis of brugada syndrome SCN5A variant carriers with negative sodium channel blocker challenge

Key Points

Implication

Abstract

Discussion

Cite This Study

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