What question did this study set out to answer?

To identify core ginseng compounds and their mechanisms in colorectal cancer treatment.

Mechanistic Study of Traditional Chinese Medicine Compound Containing Ginseng Radix et Rhizoma in the Treatment of Colorectal Cancer

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Mechanistic study reveals ginseng compounds influence CRC outcomes through EGFR and TP53, suggesting clinical applications.

To identify core ginseng compounds and their mechanisms in colorectal cancer treatment.
Integrated data mining with network pharmacology to analyze ginseng prescriptions.
Standardized herb information and performed cluster analysis and frequency statistics.
Conducted molecular docking to assess ligand–target binding affinities.
Core combination of ginseng, atractylodis, and glycyrrhizae identified as significant for anti-CRC effects.
Key targets include EGFR and TP53, with enriched pathways like MAPK and PD-1/PD-L1.
Molecular docking analyses confirmed favorable interactions between compounds and targets.

Yue et al. (2026) studied this question.

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