Key result
Ginseng may regulate the colorectal cancer tumor microenvironment through 22 active ingredients and 202 targets, with SRC, STAT3, PIK3R1, HSP90AA1, and AKT1 identified as core targets.
Why the study?
To investigate the potential mechanism of action of ginseng in the treatment of colorectal cancer by regulating the tumor microenvironment.
Network pharmacology and bioinformatics analysis suggests ginseng may regulate the tumor microenvironment in colorectal cancer through multi-target pathways including SRC, STAT3, PIK3R1, HSP90AA1, and AKT1.
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Does not support clinical use in colorectal cancer; hypothesis-generating for ginseng's multi-target effects on the tumor microenvironment.
Wang et al. (2023) studied Colorectal cancer. Ginseng was evaluated on Core targets and pathways of ginseng in colorectal cancer tumor microenvironment. Ginseng may regulate the colorectal cancer tumor microenvironment through 22 active ingredients and 202 targets, with SRC, STAT3, PIK3R1, HSP90AA1, and AKT1 identified as core targets.
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