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March 14, 2026Alzheimer s & Dementia0 citationsOpen Access

APOE and plasma AD biomarkers: The role of genetic ancestry in Hispanics/Latinos

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CCCaitlin CheungBeth Israel Deaconess Medical CenterNANatasha Z. AnitaUniversity of California, San DiegoPFPaola FiligranaAlbert Einstein College of Medicine

Key Points

  • To explore the influence of genetic ancestry on APOE-associated Alzheimer's disease risk in Hispanic/Latino populations.
  • Examined prior research on APOE and AD biomarkers in Hispanic/Latino groups.
  • Analyzed the relationship between genetic ancestry and AD risk.
  • Considered the role of ancestry-based heterogeneity in biomarker research.
  • Genetic ancestry modifies the risk associated with APOE in Alzheimer's disease.
  • Calls for capturing ancestry-based differences in AD biomarker studies.

Abstract

These findings expand on prior studies suggesting that genetic ancestry modifies APOE-associated AD risk in Hispanic/Latino populations and highlight the importance of capturing ancestry-based heterogeneity in AD biomarker research.

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Cite This Study

Cheung et al. (2026) studied this question.

synapsesocial.com/papers/69b4ba2718185d8a39802e0chttps://doi.org/10.1002/alz.71213
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