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March 14, 2026Cellular and Molecular NeurobiologyOpen Access

Interplay Between Autophagy, Cellular Senescence, and Brain Aging: Neuroprotective Implications of Intermittent Fasting

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Authors

ISIshika SinghSBShreya BhatRTRajesh Tamatta

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Overview

Observational study reviews the effects of intermittent fasting on autophagy and senescence in brain aging, suggesting neuroprotective benefits.

Key Points

  • This research aims to explore the links between autophagy, cellular senescence, and brain aging in the context of intermittent fasting.
  • Reviewed literature on autophagy and cellular senescence related to brain aging.
  • Examined the physiological effects of intermittent fasting on autophagy pathways.
  • Analyzed the role of AMPK and Sirtuin 1 in regulating autophagy.
  • Intermittent fasting promotes autophagy activation while inhibiting mTOR.
  • Autophagy function declines with age, contributing to neurodegenerative disease risk.
  • Intermittent fasting may help in clearing senescent cells in the brain.

Cite This Study

Singh et al. (2026) studied this question.

synapsesocial.com/papers/69b4fac6b39f7826a300b6e9https://doi.org/10.1007/s10571-026-01709-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Autophagy Stimulation by Intermittent Fasting and Its Potential Neuroprotective Role in Alzheimer’s Disease2026
  2. 2Fasting and Autophagy: Clinical Significance for Longevity2025
  3. 3Regulatory impact of intermittent fasting on autophagy in high fat diet induced structural and cognitive brain deteriorations in rats2026
  4. 4Regulation of autophagy‐mediated pathways by diet, physical activity, and sleep in Alzheimer's disease2026 · 4 citations
  5. 5Effects of intermittent fasting on brain health via the gut–brain axis2025