Potassium tert -Butoxide-Mediated Isomerization of Alkenes: A Versatile Protocol for Miscellaneous Substrates

The development of rapid and efficient routes to alkene derivatives remains a significant priority due to their broad utility as building blocks and valuable compounds. Herein, we report a simple, general, and highly efficient procedure for the (catalytic) isomerization of alkenes under mild conditions. This method is applicable to a wide range of substrates, including allylic derivatives of benzenes, aromatic and aliphatic systems, heterocycles, ethers, thioethers, amines, and sulfones. In this transformation, KOtBu acts as both the base and the proton shuttle, enabling the reaction to proceed under air and affording quantitative yields within minutes for the majority of the substrates examined. The reaction occurs under thermodynamic control, affording the most stable isomer (typically, the E-alkene).