What question did this study set out to answer?

This study aims to examine the prevalence of acute kidney injury (AKI) in immunocompromised patients experiencing acute respiratory failure and assess the risk linked to mechanical ventilation.

March 14, 2026Annals of Intensive CareOpen Access

Acute kidney injury in immunocompromised patients with acute respiratory failure: insights from the HIGH clinical trial and relation with mechanical ventilation

View Full Paper

Ask AI

Bookmark

Authors

AJAdrien JosephInserm MDMichaël DarmonInserm LALaurent ArgaudUniversité Claude Bernard Lyon 1

Discussion

Member takes

Implication

Analysis explores acute kidney injury prevalence and mechanical ventilation risks in immunocompromised patients, indicating complexities in treatment decisions.

Key Points

This study aims to examine the prevalence of acute kidney injury (AKI) in immunocompromised patients experiencing acute respiratory failure and assess the risk linked to mechanical ventilation.
Post-hoc analysis of 734 immunocompromised patients from the HIGH clinical trial.
Evaluation of AKI prevalence and its association with mechanical ventilation.
Used causal inference models adjusted for the likelihood of requiring ventilation.
74% of patients developed AKI, while 41% required invasive mechanical ventilation.
AKI often occurred before ventilation, with the median peak KDIGO stage at 2 days.
Univariate analysis showed a significant association between ventilation and AKI, but not in multivariate analysis.

Cite This Study

Joseph et al. (2026) studied this question.

synapsesocial.com/papers/69b4fbc1b39f7826a300c2a3 https://doi.org/10.1016/j.aicoj.2026.100048

View Full Paper

Ask AI

Bookmark

Implication

Analysis explores acute kidney injury prevalence and mechanical ventilation risks in immunocompromised patients, indicating complexities in treatment decisions.

Acute kidney injury in immunocompromised patients with acute respiratory failure: insights from the HIGH clinical trial and relation with mechanical ventilation

Discussion

Member takes

Implication

Key Points

Cite This Study

Acute kidney injury in immunocompromised patients with acute respiratory failure: insights from the HIGH clinical trial and relation with mechanical ventilation

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider