Quantifying myocardial function characteristic with myocardial work measurement in patients with different aortic regurgitation severity

Non-invasive MW indices, particularly GWW and GWE, progressively deteriorate with AR severity in preserved LVEF patients. These findings provide novel, physiology-based insights into myocardial energetic efficiency in chronic volume overload. MW parameters may offer incremental value in functional evaluation, potentially aiding subclinical dysfunction identification. Future large-scale, longitudinal studies are warranted to validate prognostic utility and role in optimizing intervention timing.