Latest developments in urinary tumor DNA and its current clinical role in urothelial bladder cancer and upper tract urothelial carcinoma

Key Points

• To explore the clinical role of urinary tumor DNA in diagnosing urothelial bladder cancer and upper tract urothelial carcinoma.
• Analysis of accumulating evidence on utDNA in urothelial carcinoma diagnosis
• Review of preliminary studies regarding sensitivity and specificity of utDNA.
• Urinary tumor DNA shows sensitivity of 80-90% in detecting urothelial carcinoma
• Specificity of urDNA tests is reported between 90-100%
• Further studies are recommended to validate findings and improve clinical application.