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March 15, 2026MedicineOpen Access

Rosa roxburghii Tratt. enhances fracture healing through multitarget regulation of osteogenesis and angiogenesis: Integrated network pharmacology and molecular docking analysis

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Authors

ZWZhongxiu WuPLPingping LuoHLHongshi Liu

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Overview

Network pharmacology reveals Rosa roxburghii enhances osteogenesis and angiogenesis in fracture healing, suggesting viable therapeutic pathways.

Key Points

  • This research aims to explore how Rosa roxburghii Tratt. aids in fracture healing through specific biological mechanisms.
  • Analyzed components and targets from various databases including PubChem and GeneCards.
  • Conducted Gene Ontology and KEGG analyses to uncover mechanisms of action.
  • Constructed protein-protein interaction networks to identify core targets and components.
  • Performed molecular docking to validate binding interactions between components and targets.
  • Rosa roxburghii significantly regulates pathways related to osteogenesis and angiogenesis.
  • Identified key targets such as tumor necrosis factor and phosphoinositide 3-kinase.
  • Demonstrated strong binding of active components like naringenin and isorhamnetin with the core targets.

Cite This Study

Wu et al. (2026) studied this question.

synapsesocial.com/papers/69b5ff8083145bc643d1c263https://doi.org/10.1097/md.0000000000048071
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  3. 3Network Pharmacology and Molecular Docking Combined with In Vivo Validation to Elucidate the Molecular Mechanisms of Adenophorae Radix in Fracture Healing2026 · 2 citations
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