3D-printed GelMA/BC@PLLAms-Cur@TCP-PCL-PEG bilayer scaffold for osteochondral repair

Enyi Gu; Kangyao Chen; Junfan Zheng; Hongxu Liu; Sen Zhang; Shurong Chen; Xiufeng Xiao; Tao Zhang

doi:10.1039/d5ra07655b

January 1, 2026RSC AdvancesOpen Access

3D-printed GelMA/BC@PLLAms-Cur@TCP-PCL-PEG bilayer scaffold for osteochondral repair

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Key Points

This research focuses on developing a bilayer scaffold for effective osteochondral repair.
Fabrication of a 3D-printed bilayer scaffold using GelMA and other materials.
Assessment of scaffold properties, including mechanical support and drug release profiles.
Evaluation of biological responses related to chondrogenesis and osteogenesis.
The upper layer successfully promotes chondrogenesis with collagen.
The lower layer supports mechanical integrity and provides sustained curcumin release.
Curcumin release demonstrates anti-inflammatory and osteogenic effects.

Implication

3D-printed scaffold promotes chondrogenesis and osteogenesis in osteochondral repair, indicating potential for tissue regeneration.

Abstract

A 3D-printed GelMA/BC@PLLAms-Cur@TCP-PCL-PEG bilayer scaffold was prepared. Its upper layer promotes chondrogenesis with collagen, while the lower layer provides mechanical support, sustained curcumin release for anti-inflammation and osteogenesis.

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Cite This Study

Gu et al. (2026) studied this question.

synapsesocial.com/papers/69b6068883145bc643d1c689 https://doi.org/10.1039/d5ra07655b

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3D-printed GelMA/BC@PLLAms-Cur@TCP-PCL-PEG bilayer scaffold for osteochondral repair

Key Points

Implication

Abstract

Discussion

Cite This Study

3D-printed GelMA/BC@PLLAms-Cur@TCP-PCL-PEG bilayer scaffold for osteochondral repair

Key Points

Implication

Abstract

Discussion

Cite This Study

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