3D-printed bilayer hydrogel scaffolds incorporating HAP and KGN@Lip for osteochondral regeneration

Zhenbiao Wangzi; Chengcheng Yang; Peng Yu; Xiubiao Huang; Nan Hu; Tuo Jiao; Hao Qi

doi:10.1039/d5tb02850g

January 1, 2026Journal of Materials Chemistry B

3D-printed bilayer hydrogel scaffolds incorporating HAP and KGN@Lip for osteochondral regeneration

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Key Points

The aim is to assess a 3D-printed bilayer hydrogel scaffold for osteochondral regeneration.
Used a 3D printing technique to fabricate bilayer GelMA scaffolds.
Integrated KGN@Lip (a growth factor) and HAP (a mineral) into the scaffolds.
Evaluated the performance in cartilage and bone regeneration.
Significantly improved cartilage and subchondral bone regeneration observed.
Higher integration of KGN@Lip and HAP led to better structural outcomes.

Implication

Shows enhanced osteochondral repair using 3D-printed scaffolds integrating KGN@Lip and HAP.

Abstract

A 3D-printed bilayer GelMA scaffold integrating KGN@Lip and HAP enables spatially coordinated cartilage and subchondral bone regeneration for osteochondral repair.

Discussion

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Cite This Study

Wangzi et al. (2026) studied this question.

synapsesocial.com/papers/6a2e482cb1cc60ccdea8c837 https://doi.org/10.1039/d5tb02850g

View Full Paper

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3D-printed bilayer hydrogel scaffolds incorporating HAP and KGN@Lip for osteochondral regeneration

Key Points

Implication

Abstract

Discussion

Cite This Study

3D-printed bilayer hydrogel scaffolds incorporating HAP and KGN@Lip for osteochondral regeneration

Key Points

Implication

Abstract

Discussion

Cite This Study

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