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March 15, 2026CureusOpen Access

Non-operative Management of Uncomplicated Appendicitis: A Review of Indications, Safety, and Clinical Algorithms

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Authors

MBMohamed BaanaMSMeghana SinghMBMoses Banfa

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Overview

Narrative review highlights non-operative management with antibiotics for uncomplicated appendicitis, suggesting safe alternatives to surgery for adults and children.

Key Points

  • To review the indications, safety, and protocols for non-operative management of uncomplicated appendicitis.
  • Narrative review of existing literature
  • Summarizes key randomized trials and systematic reviews
  • Evaluates treatment protocols and clinical algorithms
  • Considers special populations such as paediatric and pregnant patients
  • Antibiotic-only treatment shows high initial success rates
  • Low rates of severe adverse events compared to surgery
  • Economically viable alternatives to operative management
  • Evidence-informed algorithms proposed for decision-making

Cite This Study

Baana et al. (2026) studied this question.

synapsesocial.com/papers/69b6068883145bc643d1c91bhttps://doi.org/10.7759/cureus.105154
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Current Management of Uncomplicated Acute Appendicitis: A Narrative Review of Nonoperative and Surgical Strategies2026
  2. 2Nonoperative Management of Uncomplicated Acute Appendicitis: A Systematic Review and Meta‐Analysis of Randomized Clinical Trials Comparing Antibiotic Treatment and Appendectomy in Children and Adolescents2026 · 1 citations
  3. 3WHO CAN SAFELY SKIP SURGERY? PREDICTORS OF SUCCESS AND FAILURE OF NONOPERATIVE MANAGEMENT IN ACUTE UNCOMPLICATED APPENDICITIS2026
  4. 4Suspected Simple Appendicitis in Children: Should We Use a Nonoperative, Antibiotic-Free Approach? An Observational Study2024 · 5 citations
  5. 5Does non-operative treatment of appendicitis can replace surgery? - literature overview2024