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June 12, 2026International Journal of Innovative Technologies in Social ScienceOpen Access

Who Can Safely Skip Surgery? Predictors of Success and Failure of Nonoperative Management in Acute Uncomplicated Appendicitis

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Authors

OGOliwia GrzelakWKWeronika KuśmierczykOBOliwia Bolek

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Overview

Review identifies factors influencing treatment outcomes of nonoperative management in appendicitis, suggesting improved patient selection.

Key Points

  • This review aims to summarize evidence on predictors of success and failure of nonoperative management (NOM) in acute uncomplicated appendicitis.
  • Literature search conducted in PubMed, Embase, Google Scholar, and Web of Science for studies from January 2000 to January 2025.
  • Included randomized controlled trials, observational studies, systematic reviews, and meta-analyses of NOM outcomes.
  • Results were synthesized narratively due to heterogeneity among studies.
  • NOM demonstrated noninferiority to surgical treatment; 24% of patients required subsequent appendectomy.
  • Appendicolith presence was the most consistent predictor of NOM failure and recurrence.
  • Increased appendiceal diameter, elevated C-reactive protein levels, and fever were associated with poorer outcomes.

Cite This Study

Grzelak et al. (2026) studied this question.

synapsesocial.com/papers/6a2ba20e8101cf8926f011ebhttps://doi.org/10.31435/ijitss.1(49).2026.4817
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Predictors of Nonoperative Management Failure and Recurrence in Adults with Acute Appendicitis: A Single-Center Retrospective Study2022
  2. 2Success Rate of Nonoperative Management for Acute Uncomplicated Appendicitis: Retrospective Cohort Study2026
  3. 3Non-operative Management of Uncomplicated Appendicitis: A Review of Indications, Safety, and Clinical Algorithms2026
  4. 4Outcomes of Nonoperative Management of Uncomplicated Appendicitis2017 · 45 citations
  5. 5Nonoperative vs Operative Treatment of Pediatric Appendicitis2026