Key result
In adults with acute appendicitis undergoing nonoperative management, the presence of fecal stones with abscess formation was independently associated with treatment failure (OR 5.530).
Why the study?
Failure and recurrence are concerns in nonoperative management for acute appendicitis and interval appendectomy, prompting a search for predictive factors.
What are the predictors of nonoperative management failure and recurrence in adults with acute appendicitis?
Population
337 adults with acute appendicitis who did not undergo emergency surgery
Comparison
Failed vs successful nonoperative management, and recurrence vs non-recurrence
Design
Single-center retrospective study
Authors
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Fecalith with abscess may flag nonoperative failure risk in appendicitis; hypothesis-generating and should not yet change practice.
Cohort (n=337)
No
What are the predictors of nonoperative management failure and recurrence in adults with acute appendicitis?
Odds Ratio: 5.53 (95% CI 2.081–14.691)
p-value: p=0.001
Post-treatment CRP levels and the presence of fecal stones with abscess formation are strong independent predictors of nonoperative management failure in adults with acute appendicitis.
Wakasa et al. (2022) conducted a cohort in Acute appendicitis (n=337). Fecal stones with abscess formation vs. Absence of fecal stones with abscess formation was evaluated on Nonoperative management (NOM) failure (OR 5.530, 95% CI 2.081-14.691, p=0.001). In adults with acute appendicitis undergoing nonoperative management, the presence of fecal stones with abscess formation was independently associated with treatment failure (OR 5.530).
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