Key result
The presence of fecal stones with abscess formation (OR 5.530) and higher posttreatment CRP levels were independently associated with nonoperative management failure in adults with acute appendicitis.
Why the study?
Failure and recurrence are concerns in nonoperative management for acute appendicitis and interval appendectomy.
What are the predictors of nonoperative management failure and recurrence in adults with acute appendicitis?
Observational (n=348)
No
What are the predictors of nonoperative management failure and recurrence in adults with acute appendicitis?
Odds Ratio: 5.53 (95% CI 2.081–14.691)
p-value: p=0.001
Posttreatment CRP levels and the presence of fecal stones with abscess formation are strong independent predictors of nonoperative management failure in adults with acute appendicitis.
May flag high-risk appendicitis patients for closer monitoring or surgery; hypothesis-generating and requires prospective validation.
Purpose: Failure and recurrence are concerns in nonoperative management (NOM) for acute appendicitis (AA) and interval appendectomy (IA). The goal of the study was to identify predictors of failure and recurrence in patients with AA who underwent NOM.
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Wakasa et al. (2023) conducted an observational in Acute appendicitis (n=348). Fecal stones with abscess formation vs. Absence of fecal stones with abscess formation was evaluated on Nonoperative management (NOM) failure (OR 5.530, 95% CI 2.081-14.691, p=0.001). The presence of fecal stones with abscess formation (OR 5.530) and higher posttreatment CRP levels were independently associated with nonoperative management failure in adults with acute appendicitis.
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