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March 15, 2026PLoS BiologyOpen Access

Non-peptide dysbiosis metabolites reprogram a peptide quorum-sensing receptor to induce sustained predation in beneficial streptococci

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Authors

GCGuillaume CerckelUCLouvainDDDenis DereinneUCLouvainLLLaura Ledesma-GarcíaUCLouvain

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Implication

Research demonstrates predation induction in Streptococcus salivarius by hydroxyphenylacetic acid, highlighting oral microbiome communication.

Key Points

  • This research investigates the activation of quorum sensing in Streptococcus salivarius by non-peptide metabolites.
  • Screened ~200 organic compounds for activation of ComR in Streptococcus salivarius.
  • Utilized biochemical and genetic approaches to test binding and expression of bacteriocins.
  • Analyzed the effect of hydroxyphenylacetic acid on predatory behavior in the bacterium.
  • Hydroxyphenylacetic acid effectively activates ComR in Streptococcus salivarius.
  • The activation leads to sustained expression of predatory bacteriocins.
  • Porphyromonas gingivalis produces HPAA, facilitating predation via metabolite-driven activation.

Cite This Study

Cerckel et al. (2026) studied this question.

synapsesocial.com/papers/69b6069b83145bc643d1c9a3https://doi.org/10.1371/journal.pbio.3003718
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Also Consider

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  4. 4Nitration of the salivary component 4‐hydroxyphenylacetic acid in the human oral cavity: enhancement of nitration under acidic conditions2009 · 17 citations
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