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August 26, 2025Journal of BacteriologyOpen Access

RRNPP quorum-sensing repertoires in the salivarius group genomes: overrepresentation and synchronous activation of SHP/Rgg systems in Streptococcus thermophilus

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Authors

QCQuentin CaillotAGAlain GuillotTLThomas Lacroix

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Overview

Analysis shows activation of Rgg regulators in Streptococcus thermophilus, indicating potential for quorum sensing manipulation.

Key Points

  • S. thermophilus exhibits a high prevalence of Rgg regulators, activated by SHP pheromones to control RaS-RiPP production.
  • Liquid chromatography-high resolution tandem mass spectrometry identified novel SHPs and RaS-RiPPs, with functional activity observed in most systems.
  • The study revealed that SHPs are transiently present during growth, while RaS-RiPPs accumulate, suggesting different roles in signaling.
  • Manipulating quorum sensing through SHP addition to growth medium may have significant implications for strain management.

Cite This Study

Caillot et al. (2025) studied this question.

synapsesocial.com/papers/68af6203ad7bf08b1eae2d05https://doi.org/10.1128/jb.00231-25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Interplay between different SHP/Rgg quorum sensing systems that control production of post-translationally modified peptides in Streptococcus thermophilus2026
  2. 2Rgg/SHP transcriptional regulators, RaS-RiPPs, and their impacts in streptococci2026
  3. 3Impact of the RaS-RiPP tryglysin and culturing conditions on ex-vivo oral microbiomes2025
  4. 4Non-peptide dysbiosis metabolites reprogram a peptide quorum-sensing receptor to induce sustained predation in beneficial streptococci2026
  5. 5Use of Rgg quorum-sensing machinery to create an innovative recombinant protein expression system in Streptococcus thermophilus2024 · 4 citations