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September 10, 2025npj Biofilms and MicrobiomesOpen Access

Impact of the RaS-RiPP tryglysin and culturing conditions on ex-vivo oral microbiomes

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Authors

BRBritta E. RuedADAchal DhariwalBCBrett C. Covington

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Overview

This research reveals how RaS-RiPPs affect the ex-vivo oral microbiome, indicating key culturing factors.

Key Points

  • Ex-vivo culturing conditions significantly influence the composition of oral microbiomes, particularly bacterial and fungal diversity.
  • RaS-RiPP Tryglysin A modulates growth and may enhance antibiotic tolerance in Streptococcus species.
  • Medium selection and atmosphere during cultivation can alter the presence of oral microbiome constituents.
  • The study lays groundwork for future research on the role of natural products in oral health and disease.

Cite This Study

Rued et al. (2025) studied this question.

synapsesocial.com/papers/68c1b19354b1d3bfb60e8b08https://doi.org/10.1038/s41522-025-00794-8
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