What does this research mean for the field?

In Streptococcus thermophilus, SHP/Rgg quorum sensing systems exhibit significant crosstalk, where operons can be co-regulated by multiple Rgg regulators, single Rggs can be activated by multiple SHPs, and systems can integrate with the ComR/S pathway to produce novel post-translationally modified peptides. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To investigate potential cross-activation and regulatory crosstalk among five distinct SHP/Rgg quorum-sensing systems that control the production of ribosomally synthesized and post-translationally modified peptides in Streptococcus thermophilus.

August 27, 2026MicrobiologyOpen Access

Interplay between different SHP/Rgg quorum sensing systems that control production of post-translationally modified peptides in Streptococcus thermophilus

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Authors

QCQuentin Caillot AGAlain Guillot AGAlexandre de Saint Germain

Discussion

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Overview

In vitro genetic analysis reveals crosstalk among distinct quorum sensing systems in Streptococcus thermophilus, indicating complex regulatory networks for specialized peptide production.

Key Points

To investigate potential cross-activation and regulatory crosstalk among five distinct SHP/Rgg quorum-sensing systems that control the production of ribosomally synthesized and post-translationally modified peptides in Streptococcus thermophilus.
Constructed reporter fusions across different genetic backgrounds to analyze transcriptional activation by Rgg regulators and short hydrophobic peptides (SHPs).
Characterized post-translationally modified peptide production using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
Each Rgg regulator activated transcription of its proximal operon, while cross-activation occurred through both individual operon co-regulation by two distinct Rgg regulators and single Rgg activation by multiple SHPs.
Identified a novel peptide operon (producing ThiF-like RiPP 6405) co-regulated by two distinct quorum-sensing pathways: an SHP/Rgg system and the ComR/S competence system.

Cite This Study

Caillot et al. (2026) studied this question.

synapsesocial.com/papers/6a8fe9b910c91c1e926219d5 https://doi.org/10.1099/mic.0.001761

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August 27, 2026MicrobiologyOpen Access

Interplay between different SHP/Rgg quorum sensing systems that control production of post-translationally modified peptides in Streptococcus thermophilus

View Full Paper

Ask AI

Bookmark

Authors

QCQuentin Caillot AGAlain Guillot AGAlexandre de Saint Germain

Discussion

Member takes

Overview

In vitro genetic analysis reveals crosstalk among distinct quorum sensing systems in Streptococcus thermophilus, indicating complex regulatory networks for specialized peptide production.

Key Points

To investigate potential cross-activation and regulatory crosstalk among five distinct SHP/Rgg quorum-sensing systems that control the production of ribosomally synthesized and post-translationally modified peptides in Streptococcus thermophilus.
Constructed reporter fusions across different genetic backgrounds to analyze transcriptional activation by Rgg regulators and short hydrophobic peptides (SHPs).
Characterized post-translationally modified peptide production using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
Each Rgg regulator activated transcription of its proximal operon, while cross-activation occurred through both individual operon co-regulation by two distinct Rgg regulators and single Rgg activation by multiple SHPs.
Identified a novel peptide operon (producing ThiF-like RiPP 6405) co-regulated by two distinct quorum-sensing pathways: an SHP/Rgg system and the ComR/S competence system.

Cite This Study

Caillot et al. (2026) studied this question.

synapsesocial.com/papers/6a8fe9b910c91c1e926219d5 https://doi.org/10.1099/mic.0.001761

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