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Findings reveal RNA polymerase II degradation by OROV NSs in host cells, suggesting immune evasion mechanisms.
OROV NSs suppresses host transcription via nucleolar targeting and RNAPII degradation and partially modulates IFN-I signaling downstream of IFNAR activation, representing an evolutionarily acquired immune evasion mechanism. These findings enhance our understanding of OROV pathogenesis and help to identify NSs as a potential antiviral target.
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Yoshikawa et al. (2026) studied this question.
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