March 15, 2026Clinical Infectious Diseases1 citationsOpen Access

Patterns of HIV-1 viral load suppression and drug resistance during the dolutegravir transition: a population-based longitudinal study

MMMarc MartínGeorgia Institute of Technology ABAlexandra BlenkinsopNIHR Imperial Biomedical Research Centre MMMichelle MoffaUniversity of North Carolina at Chapel Hill

Key Points

This study examines patterns of HIV-1 viral load suppression and drug resistance during the transition to dolutegravir.
Population-based longitudinal study
Examined treatment-experienced people living with HIV (PLHIV)
Monitored viral load and drug resistance over time
Viral suppression increased during the dolutegravir transition
Minimal emergence of intermediate/high-level drug resistance
Reduction in viremia strongly linked to ART adherence

Abstract

Viral suppression increased during the DTG-transition with minimal emerging intermediate/high-level resistance. Falling resistance among treatment-experienced PLHIV underscores the role of ART adherence in reducing viremia. The emergence of inS153Y justifies continued surveillance.

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