Expression of concern raised regarding data integrity in a study exploring dexmedetomidine's effects on sepsis-associated encephalopathy.
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that western blot data featured in Fig. 4A were strikingly similar to data that appeared subsequently in the journal Journal of Clinical Science that was written by different authors. Additionally, the right‑hand β‑actin band in Fig. 1A was apparently the same as the left‑hand β‑actin band in Fig. 1B; the right‑hand band in the gel for cleaved caspase‑3 in Fig. 5A was apparently the same as the left‑hand protein band for the Bcl‑2 blots in Fig. 5B; and the β‑actin bands in Fig. 4A seemed to match with most of the β‑actin bands in Fig. 1A. The authors have been contacted by the Editorial Office to offer an explanation for these apparent anomalies in the presentation of the data in this paper; however, up to this time, no response from them has been forthcoming. Owing to the fact that the Editorial Office has been made aware of potential issues surrounding the scientific integrity of this paper, we are issuing an Expression of Concern to notify readers of these potential problems while the Editorial Office continues to investigate this matter further. [Molecular Medicine Reports 20: 4731‑4740, 2019; DOI: 10.3892/mmr.2019.10718].
No takes yet. Share an insight, caveat, or question.
Yin et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: