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March 15, 2026Journal of Dairy ScienceOpen Access

Comprehensive investigation of milk-derived extracellular vesicles on intestinal stem cell–based models

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Authors

HWHailong WangSouth China Agricultural University XZXiaoling ZengChina Nonferrous Metals Changsha Investigation Design Institute SWShumeng WangSouth China Agricultural University

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Implication

This investigation shows the effects of milk-derived extracellular vesicles on intestinal stem cell models, indicating their potential role in gut health.

Key Points

The study aims to explore the effects of milk-derived extracellular vesicles on models of intestinal stem cells.
Established three types of intestinal stem cell-based models from piglet intestine.
Assessed physiological properties including cell composition and fatty acid uptake.
Examined the uptake of porcine MEV using organoid models and endocytosis inhibitors.
Organoid monolayer and apical-out organoids internalized MEV effectively.
MEV boosted the expression of stemness and differentiation-related genes in colon-derived stem cells.
Uptake of MEV was inhibited by endocytosis blockers, confirming the uptake mechanism.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69b64c33b42794e3e660d96f https://doi.org/10.3168/jds.2025-26745

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Implication

This investigation shows the effects of milk-derived extracellular vesicles on intestinal stem cell models, indicating their potential role in gut health.

Comprehensive investigation of milk-derived extracellular vesicles on intestinal stem cell–based models

Discussion

Member takes

Implication

Key Points

Cite This Study

Comprehensive investigation of milk-derived extracellular vesicles on intestinal stem cell–based models

Discussion

Member takes

Implication

Key Points

Cite This Study

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