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March 1, 2026Kidney MedicineOpen Access

Association of IV vs. Oral Iron Therapy With Clinical Outcomes in Patients With Advanced CKD

Adedamola M. Adeboye Prabin Shrestha Keiichi Sumida Fridtjof Thomas Connie M. Rhee Kamyar Kalantar-Zadeh Csaba P. Kövesdy

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Key Points

This study aims to compare the long-term outcomes of intravenous (IV) versus oral iron therapy in patients with chronic kidney disease.
Investigated a national cohort of U.S. Veterans with eGFR less than 60 ml/min/1.73m².
Compared 17,428 new users of oral iron to 879 new users of IV iron.
Utilized competing risk regression and Cox models for analysis.
Employed propensity score matching to adjust for baseline differences.
Higher event rates were observed in the IV iron group; however, this difference became non-significant after matching.
No significant association found between IV iron therapy and the risk of incident ESKD (subhazard ratio: 1.07).
No significant association found between IV iron therapy and all-cause mortality (hazard ratio: 1.07).

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Implication

National cohort study compares iron therapy types and their effects on mortality and ESKD in CKD patients, suggesting no significant differences.

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Cite This Study

Adeboye et al. (2026) studied this question.

synapsesocial.com/papers/69b64c9ab42794e3e660dd25 https://doi.org/10.1016/j.xkme.2026.101324

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Role of Parenteral Iron Therapy in Chronic Kidney Disease PatientsCohort Study · 2026
2Influence of intravenous iron therapy on mortality and cardiovascular events of patients on hemodialysis: A meta-analysis2025
3Optimal Oral Iron Therapy for Iron Deficiency Anemia Among US Veterans2024 · 6 citations
4Does Intravenous Iron Improve Survival and Physical Function and Reduce Heart Failure Events in Patients with Chronic Kidney Disease?review · 2026
5Intravenous iron therapy for patients with heart failure: a meta-analysis stratified by chronic kidney disease statusmeta-analysis · 2026

Comparison of administration of oral versus Infusions intravenous iron therapy in diabetic patients with chronic kidney disease receiving Erythropoietin2025
Comparison of Oral Versus Intravenous Iron Therapy in Improving Hemoglobin Status in Patients of Chronic Kidney Disease2024
A systematic review investigating the safety and efficacy of intravenous iron in people with ND-CKD who are iron deficient but not anaemic2026
Mucosal Inflammation as a Driver of Gd-IgA1 Production in IgA Nephropathy: Mechanistic Support for Targeted TherapiesKidney Medicine · 2026
Blood Pressure Level and Risk of Cardiovascular Disease Mortality in Patients With Kidney Failure on Maintenance Peritoneal Dialysis: A Sub-AnalysisKidney Medicine · 2026

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