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March 15, 2026ESMO Open0 citationsOpen Access

Progression patterns and clinical outcomes in patients with cutaneous squamous-cell carcinoma following anti-PD-1 therapy failure

KKKaram KhaddourPKPamela KoteMLM. Liu

Key Points

  • The aim is to explore progression patterns and clinical outcomes in cutaneous squamous-cell carcinoma after anti-PD-1 therapy failure.
  • Cohort study design
  • Assessment of progression patterns following anti-PD-1 therapy
  • Evaluation of overall survival in relation to prior chemotherapy and treatments
  • Identification of TMB levels linked to treatment response
  • Distant metastatic and locoregional progression were the main patterns observed after anti-PD-1 failure.
  • Lower tumor mutational burden (TMB) was associated with primary resistance to therapy.
  • Prior chemotherapy correlated with poorer overall survival (OS).
  • Some patients showed benefit from subsequent treatments like cetuximab and local therapy.

Abstract

In this cohort of patients with CSCC, distant metastatic and locoregional progression were the predominant patterns following anti-PD-1 failure, with lower TMB linked to primary resistance. Prior chemotherapy was associated with poorer OS. Select patients benefited from subsequent treatments, including cetuximab and local therapy.

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Cite This Study

Khaddour et al. (2026) studied this question.

synapsesocial.com/papers/69b64c9ab42794e3e660ddfchttps://doi.org/10.1016/j.esmoop.2026.106081
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