Progression patterns and clinical outcomes in patients with cutaneous squamous-cell carcinoma following anti-PD-1 therapy failure

Karam Khaddour; Pamela Kote; M. Liu; Anita Giobbie-Hurder; I. Dryg; A. Goyal; J.P. Guenette; JD Schoenfeld; D.N. Margalit; R.B. Tishler; E.M. Rettig; R.K.V. Sethi; D.J. Annino; L.A. Goguen; R. Uppaluri; Charles H. Yoon; Michele De Simone; N.A. Ran; Jennifer L. Stevens; A.H. Waldman; E.S. Ruiz; J. Cohen; A. Silk; G.J. Hanna

doi:10.1016/j.esmoop.2026.106081

Key Points

The aim is to explore progression patterns and clinical outcomes in cutaneous squamous-cell carcinoma after anti-PD-1 therapy failure.
Cohort study design
Assessment of progression patterns following anti-PD-1 therapy
Evaluation of overall survival in relation to prior chemotherapy and treatments
Identification of TMB levels linked to treatment response
Distant metastatic and locoregional progression were the main patterns observed after anti-PD-1 failure.
Lower tumor mutational burden (TMB) was associated with primary resistance to therapy.
Prior chemotherapy correlated with poorer overall survival (OS).
Some patients showed benefit from subsequent treatments like cetuximab and local therapy.

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Implication

Cohort observes progression patterns and outcomes in cutaneous squamous-cell carcinoma, suggesting varied treatment responses.

Abstract

In this cohort of patients with CSCC, distant metastatic and locoregional progression were the predominant patterns following anti-PD-1 failure, with lower TMB linked to primary resistance. Prior chemotherapy was associated with poorer OS. Select patients benefited from subsequent treatments, including cetuximab and local therapy.

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Cite This Study

Khaddour et al. (2026) studied this question.

synapsesocial.com/papers/69b64c9ab42794e3e660ddfc https://doi.org/10.1016/j.esmoop.2026.106081

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Progression patterns and clinical outcomes in patients with cutaneous squamous-cell carcinoma following anti-PD-1 therapy failure

Key Points

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Implication

Abstract

Discussion

Cite This Study

Progression patterns and clinical outcomes in patients with cutaneous squamous-cell carcinoma following anti-PD-1 therapy failure

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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