What does this research mean for the field?

Intraductal papilloma can exhibit sebaceous metaplasia, a rare finding in breast lesions. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research describes the rare occurrence of sebaceous metaplasia in benign intraductal papillomas.

March 15, 2026Open Access

Two Cases of Intraductal Papilloma with Sebaceous Metaplasia of the Breast

KOKurumi OkadaKobe City Nishi-Kobe Medical Center TTTakashi TashiroNihon University TOT. OkunoKobe City Nishi-Kobe Medical Center

Key Points

This research describes the rare occurrence of sebaceous metaplasia in benign intraductal papillomas.
Detailed histological examination of surgically resected breast tissue
Analysis of imaging findings preceding surgery
Case reporting of two individual patients
Both cases were histologically confirmed as benign
Sebaceous metaplasia was identified, marking a rare presentation
Imaging results initially suggested possible malignancy

Abstract

INTRODUCTION: Intraductal papilloma is a common benign breast lesion that typically presents with nipple discharge or a palpable mass. While apocrine metaplasia is frequently observed, sebaceous metaplasia is very rare in breast lesions, with only a few cases reported to date. We herein describe two surgically resected cases of intraductal papilloma with sebaceous metaplasia, both of which were histologically proven benign following imaging findings that were suspicious for malignancy.

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