What question did this study set out to answer?

Investigate the impact of preexisting anti-HLA-DQ donor-specific antibodies on kidney transplant outcomes.

March 16, 2026SHILAP Revista de lepidopterologíaOpen Access

Effect of preexisting human leukocyte antigen donor-specific antibodies especially human leukocyte antigen-DQ on kidney transplant outcome

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Authors

SMSonia MehrotraMedanta The Medicity RSRaj Kumar SharmaMedanta The Medicity RKRakesh KapoorMedanta The Medicity

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Implication

This analysis finds that preexisting HLA-DQ antibodies influence rejection risk in kidney transplant recipients, indicating the need for careful monitoring.

Key Points

Investigate the impact of preexisting anti-HLA-DQ donor-specific antibodies on kidney transplant outcomes.
Evaluated 119 kidney transplant recipients for pre-transplant HLA sensitization using SAB assays.
Assessed both class I and II donor-specific antibodies in all patients.
Monitored patients for a minimum of 4 years post-transplant, focusing on immunosuppression strategies.
34% of recipients had class I HLA antibodies without rejection episodes.
38% tested positive for class II HLA antibodies, with 20 having anti-HLA-DQ.
Only one DQ DSA-positive patient developed biopsy-proven rejection, later recovering.

Cite This Study

Mehrotra et al. (2026) studied this question.

synapsesocial.com/papers/69b79d538166e15b153aac67 https://doi.org/10.3389/fneph.2026.1734903

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Implication

This analysis finds that preexisting HLA-DQ antibodies influence rejection risk in kidney transplant recipients, indicating the need for careful monitoring.

Effect of preexisting human leukocyte antigen donor-specific antibodies especially human leukocyte antigen-DQ on kidney transplant outcome

Discussion

Member takes

Implication

Key Points

Cite This Study

Effect of preexisting human leukocyte antigen donor-specific antibodies especially human leukocyte antigen-DQ on kidney transplant outcome

Discussion

Member takes

Implication

Key Points

Cite This Study

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