What question did this study set out to answer?

To investigate the association between de novo donor-specific antibody development—particularly against HLA-DQ antigens—and post-transplant allograft function, rejection, and survival.

March 1, 2018Annals of Saudi MedicineOpen Access

Donor–specific HLA-DQ antibodies may contribute to poor graft outcome after heart transplantation

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Authors

OOOsama Ali OmraniUniversity College London Hospitals NHS Foundation Trust MAMoheeb Al‐AwwamiKing Faisal Specialist Hospital & Research Centre JBJehad Al BuraikiKing Faisal Specialist Hospital & Research Centre

Discussion

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Implication

Retrospective cohort study reveals donor-specific HLA-DQ antibodies increase rejection risk and mortality in heart transplant recipients, indicating the need for targeted matching and monitoring.

Key Points

To investigate the association between de novo donor-specific antibody development—particularly against HLA-DQ antigens—and post-transplant allograft function, rejection, and survival.
Conducted a retrospective cohort study of 127 heart transplant recipients at a tertiary center in Riyadh, Saudi Arabia (January 2006 to October 2014), excluding those with preformed donor-specific antibodies or positive pre-transplant crossmatches.
Identified anti-HLA antibodies using a Luminex-based assay alongside protocol endomyocardial biopsies performed during the first year post-transplant and annually thereafter.
De novo donor-specific antibodies developed in 34% of recipients (43/127), with 77% of antibody-positive patients (33/43) targeting HLA-DQ antigens either alone (n=7) or in combination with other HLA types (n=26).
Patients with donor-specific antibodies demonstrated significantly higher rates of treated acute cellular rejection (P = .011), reduced left ventricular ejection fraction (P < .001), cardiac allograft vasculopathy (P = .003), and all-cause mortality (P = .01).

Cite This Study

Omrani et al. (2018) studied this question.

synapsesocial.com/papers/6a96e853a45595e5080e40b4 https://doi.org/10.5144/0256-4947.2018.97

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Implication

Retrospective cohort study reveals donor-specific HLA-DQ antibodies increase rejection risk and mortality in heart transplant recipients, indicating the need for targeted matching and monitoring.

Donor–specific HLA-DQ antibodies may contribute to poor graft outcome after heart transplantation

Discussion

Member takes

Implication

Key Points

Cite This Study

Donor–specific HLA-DQ antibodies may contribute to poor graft outcome after heart transplantation

Discussion

Member takes

Implication

Key Points

Cite This Study

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