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March 16, 2026Autonomic NeuroscienceOpen Access

Site-specific role of CRF1 receptors along the rostrocaudal axis of the insular cortex in cardiovascular responses evoked by acute and repeated restraint stress in rats

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Authors

LRLilian L. Reis-SilvaUniversidade Estadual Paulista (Unesp)RTRodrigo A. TomeoUniversidade Estadual Paulista (Unesp)LBLucas Barreto-de-SouzaUniversidade Estadual Paulista (Unesp)

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Overview

Investigates cardiovascular responses in rats during stress through CRF1 receptors in the insular cortex, indicating site-specific effects.

Key Points

  • The study aims to explore how CRF1 receptors in various insular cortex subregions influence cardiovascular responses to stress.
  • Targeted microinjections of CRF1 receptor antagonist or agonist into specific insular cortex subregions
  • Assessment of arterial pressure, heart rate, and tail skin temperature
  • Comparative analysis of acute and repeated restraint stress effects
  • Microinjection of the antagonist in the aIC reduced heart rate and enhanced temperature drop during acute stress
  • Antagonist injection in the rpIC moderated blood pressure response and increased temperature drop
  • In the cpIC, the antagonist diminished both blood pressure and heart rate responses without affecting temperature
  • Repeated stress altered CRF control in specific subregions but did not change receptor expression

Cite This Study

Reis-Silva et al. (2026) studied this question.

synapsesocial.com/papers/69b79da78166e15b153aad8ahttps://doi.org/10.1016/j.autneu.2026.103403
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  1. 1The power of positive stress – a complementary commentary2019 · 42 citations
  2. 2Insular cortex corticotropin-releasing factor integrates stress signaling with social affective behavior2022 · 42 citations
  3. 3Involvement of the insular cortex in the consolidation and expression of contextual fear conditioning2013 · 55 citations
  4. 4Localization of novel corticotropin-releasing factor receptor (CRF2) mRNA expression to specific subcortical nuclei in rat brain: comparison with CRF1 receptor mRNA expression1995 · 924 citations