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October 1, 1987AJP Gastrointestinal and Liver Physiology

Corticotropin-releasing factor directly mediates colonic responses to stress

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Authors

CWCynthia L. WilliamsUniversity of MinnesotaJPJennifer M. PetersonUniversity of ToledoRVRodrigo VillarUniversity of Manitoba

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Overview

Animal study demonstrates that corticotropin-releasing factor accelerates colonic transit during stress in rats, indicating endogenous mediation of stress-related gut motor alterations.

Key Points

  • To determine whether corticotropin-releasing factor mediates stress-induced alterations in intestinal motility and whether receptor blockade prevents these motor responses.
  • Evaluated gastric emptying, small intestinal transit, colonic transit, and fecal excretion in a rat model of stress-induced intestinal dysfunction.
  • Administered exogenous corticotropin-releasing factor (0.3–10.0 µg iv or icv) to test for dose-dependent effects on gut transit.
  • Pretreated stressed rats with the receptor antagonist alpha-helical CRF-(9-41) (50 µg iv or icv) to assess pharmacological blockade of stress responses.
  • Exogenous corticotropin-releasing factor (0.3–10.0 µg iv or icv) produced dose-dependent inhibition of gastric emptying and small intestinal transit while stimulating colonic transit and fecal excretion.
  • Treatment with alpha-helical CRF-(9-41) (50 µg iv or icv) completely prevented the stress-induced increase in large intestinal transit and associated fecal excretion.

Cite This Study

Williams et al. (1987) studied this question.

synapsesocial.com/papers/6a6ffad6f44fa9f079dd7e16https://doi.org/10.1152/ajpgi.1987.253.4.g582
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Also Consider

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