What type of study is this?

This is a Animal Study study (also classified as: Observational).

Corticotropin‐releasing factor type 1 receptors in the rat nodose ganglion are involved in the transduction of stress‐induced visceral sensory signals to the brain

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Observational analysis evaluates visceral sensory signal transduction in rats, suggesting CRF involvement in stress response.

Activation of CRF type 1 receptors is crucial for transmitting stress-induced visceral sensory signals to the brain, indicating their key role.
CRF administration increased pCREB expression while vagotomy diminished CRF 1-positive cells, showcasing a dynamic interaction.
Characterization of CRF 1-like immunoreactivity was conducted in the nodose ganglion, focusing on vagal nerve functions.
These findings highlight the relevance of the CRF/CRF 1 system in understanding stress-related gut-brain communication, warranting further investigation.

Mano‐Otagiri et al. (2025) studied this question.

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View Full Paper

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Authors

Observational analysis evaluates visceral sensory signal transduction in rats, suggesting CRF involvement in stress response.

Activation of CRF type 1 receptors is crucial for transmitting stress-induced visceral sensory signals to the brain, indicating their key role.
CRF administration increased pCREB expression while vagotomy diminished CRF 1-positive cells, showcasing a dynamic interaction.
Characterization of CRF 1-like immunoreactivity was conducted in the nodose ganglion, focusing on vagal nerve functions.
These findings highlight the relevance of the CRF/CRF 1 system in understanding stress-related gut-brain communication, warranting further investigation.

Mano‐Otagiri et al. (2025) studied this question.

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