Key result
Activation of the CRF2 receptor by urocortin 3 significantly increased the mechanosensitivity of both tension and mucosal gastric vagal afferents in mice.
Why the study?
Chronic stress increases gastric vagal afferent mechanosensitivity in mice, but whether stress hormones directly modulate this mechanosensitivity was unknown.
Population
8-wk-old male C57BL/6 mice
Comparison
Presence vs absence of stress hormones
Design
In vitro single-fiber recording and quantitative RT-PCR study
Authors
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CRF2 activation may heighten GVA mechanosensitivity under stress; leaves open translation to human eating disorders.
Activation of the CRF2 receptor increases gastric vagal afferent mechanosensitivity, providing a potential mechanism for stress-induced changes in feeding behavior and gastric function.
Li et al. (2019) studied this question. Urocortin 3 (CRF2 receptor agonist) vs. Absence of stress hormones / astressin 2B was evaluated on Mechanosensitivity of tension and mucosal gastric vagal afferents. Activation of the CRF2 receptor by urocortin 3 significantly increased the mechanosensitivity of both tension and mucosal gastric vagal afferents in mice.
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