What question did this study set out to answer?

To investigate whether chronic mild stress induces mechanosensitivity in gastric vagal afferents and alters their functional interaction with leptin.

June 26, 2019Neurogastroenterology & MotilityOpen Access

Chronic stress induces hypersensitivity of murine gastric vagal afferents

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Authors

HLHui LiChinese Academy of Medical Sciences & Peking Union Medical College FBFemke Buisman‐PijlmanThe University of Melbourne MNMaria Nunez‐SalcesArla Foods (Denmark)

Discussion

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Overview

Animal study demonstrates that chronic stress elevates gastric vagal afferent mechanosensitivity and impairs leptin signaling in mice, suggesting a mechanism for functional dyspepsia.

Key Points

To investigate whether chronic mild stress induces mechanosensitivity in gastric vagal afferents and alters their functional interaction with leptin.
Eight-week-old male C57BL/6 mice were subjected to unpredictable chronic mild stress or kept under control conditions for 8 weeks.
Assessed metabolic rate, gastric emptying rate, and anxiety- and depression-like behaviors.
Used an in vitro single fiber recording technique to evaluate gastric vagal afferent mechanosensitivity and leptin modulation, alongside qRT-PCR to measure gastric leptin and nodose ganglion leptin receptor mRNA.
Stressed mice exhibited lower body weight, reduced food consumption, and increased anxiety-like behaviors compared to controls.
Mechanosensitivity of mucosal and tension-sensitive gastric vagal afferents was significantly higher in mice exposed to chronic stress.
Leptin potentiated mucosal gastric vagal afferent mechanosensitivity in control mice but failed to do so in stressed mice, which also showed reduced gastric mucosal leptin mRNA expression.

Cite This Study

Li et al. (2019) studied this question.

synapsesocial.com/papers/6a6fb696fe4101aa97dfe093 https://doi.org/10.1111/nmo.13669

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June 26, 2019Neurogastroenterology & MotilityOpen Access

Chronic stress induces hypersensitivity of murine gastric vagal afferents

View Full Paper

Ask AI

Bookmark

Authors

HLHui LiChinese Academy of Medical Sciences & Peking Union Medical College FBFemke Buisman‐PijlmanThe University of Melbourne MNMaria Nunez‐SalcesArla Foods (Denmark)

Discussion

Member takes

Overview

Animal study demonstrates that chronic stress elevates gastric vagal afferent mechanosensitivity and impairs leptin signaling in mice, suggesting a mechanism for functional dyspepsia.

Key Points

To investigate whether chronic mild stress induces mechanosensitivity in gastric vagal afferents and alters their functional interaction with leptin.
Eight-week-old male C57BL/6 mice were subjected to unpredictable chronic mild stress or kept under control conditions for 8 weeks.
Assessed metabolic rate, gastric emptying rate, and anxiety- and depression-like behaviors.
Used an in vitro single fiber recording technique to evaluate gastric vagal afferent mechanosensitivity and leptin modulation, alongside qRT-PCR to measure gastric leptin and nodose ganglion leptin receptor mRNA.
Stressed mice exhibited lower body weight, reduced food consumption, and increased anxiety-like behaviors compared to controls.
Mechanosensitivity of mucosal and tension-sensitive gastric vagal afferents was significantly higher in mice exposed to chronic stress.
Leptin potentiated mucosal gastric vagal afferent mechanosensitivity in control mice but failed to do so in stressed mice, which also showed reduced gastric mucosal leptin mRNA expression.

Cite This Study

Li et al. (2019) studied this question.

synapsesocial.com/papers/6a6fb696fe4101aa97dfe093 https://doi.org/10.1111/nmo.13669

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