In Reply to Marwaha, Shepard, and Wegner

Roshan S. Prabhu; Stuart H. Burri

doi:10.1016/j.adro.2025.101943

March 1, 2026Advances in Radiation OncologyOpen Access

In Reply to Marwaha, Shepard, and Wegner

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Key Points

The research addresses the optimization of preoperative stereotactic radiosurgery outcomes by exploring timing and dose-fractionation effects.
Analysis of local recurrence rates by lesion size in preoperative SRS cohorts
Comparison of outcomes between standard-dose and reduced-dose SRS
Designing a phase 3 randomized trial (NRG-BN2522) to compare single-fraction versus fractionated SRS
Significantly higher 2-year local recurrence with larger lesion sizes (6% for 2 cm, 20% for >2-3 cm, 25% for >3-4 cm)
Standard-dose did not reduce local recurrence risk for large tumors
Overall cavity local control was 77%, with variable rates based on lesion sizes (100%, 74%, 68%)

Implication

This reply highlights the need for further studies on dose-fractionation in preoperative stereotactic radiosurgery, indicating potential for optimization.

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Cite This Study

Prabhu et al. (2026) studied this question.

synapsesocial.com/papers/69b79da78166e15b153aaec8 https://doi.org/10.1016/j.adro.2025.101943

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In Reply to Marwaha, Shepard, and Wegner

Key Points

Implication

Discussion

Cite This Study

In Reply to Marwaha, Shepard, and Wegner

Key Points

Implication

Discussion

Cite This Study

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