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March 16, 2026BMC Health Services ResearchOpen Access

Mechanism-informed transition from pediatric to adult care in sickle cell disease: a case study

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Authors

JHJane S. HankinsSt. Jude Children's Research HospitalTATarun AuroraEmory UniversityRMRachel MatsumotoWashington University in St. Louis

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Overview

This case study demonstrates improved healthcare transition for adolescents with sickle cell disease, suggesting effective implementation strategies.

Key Points

  • The study aims to explore how to effectively implement the Six Core Elements framework in transitioning adolescents with sickle cell disease to adult care.
  • Described implementation of a 6CE-informed transition program for adolescents with sickle cell disease.
  • Created a matrix to map transition activities to the Six Core Elements framework.
  • Developed a retrospective implementation research logic model to outline causal pathways and strategies.
  • Built causal loop diagrams to illustrate the interrelationships among implementation strategies.
  • Identified four key implementation strategies: organizational directives, SCD transition team, monitoring and evaluation, and care co-location.
  • Uncovered three processes necessary for maintaining 6CE implementation: capacity development, collaboration, and leadership buy-in.
  • Proposed a mechanism-based model for healthcare transition that enhances adaptability across various healthcare settings.

Cite This Study

Hankins et al. (2026) studied this question.

synapsesocial.com/papers/69b79da78166e15b153aaee9https://doi.org/10.1186/s12913-026-14312-9
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